(3^-4)(10^-3)(125)(6)/(6^-3)(5^-4)
Since there are negative exponents, you would switch the numbers in numerator to the denominator and the numerator.
(6^3)(5^4)(125)(6)/(3^4)(10^3)
Then you would simplify the fraction above.
101,250,000/81,000=1250
1250=1.25*10^3