Answer:
Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types. Systemic toxicity with reflex on the central nervous and cardiovascular systems is their most feared adverse reactions, and the anaphylactic reaction is the most concerning one. Although potentially fatal, these events are extremely rare, so local anesthetics are considered safe for use in in-office procedures.
Explanation:
Extracellular recordings represent a very powerful technique for investigating the function within CNS pathways, since it provides both high-resolution information from neural tissue in vivo and in vitro and information on the spiking (output) and synaptic activity (input) of neurons in a particular recorded area.
Intracellular recordings (red trace) occur inside an individual cell, whereas extracellular recordings (blue trace) occur outside the cell and often result in the recording of activity from several different cells.17 Oct 2018
