At a constant gfr, as plasma concentration of a freely filtered substance rises, the tubular load of the substance must, rise in direct proportion to plasma concentration.
GFR ( glomerular filtration rate )is often regarded as the best overall measure of kidney function and the most significant metric to assess in clinical kidney function evaluations.
GFR corresponds well, if not precisely, with the chance of developing renal disease consequences such as cardiovascular disease, anemia, hyperphosphatemia, and uremic symptoms.
A chronically low GFR (60 mL/min/1.73 m2) is enough to diagnose CKD regardless of the presence or absence of other signs of renal impairment.
GFR is the rate at which fluid is filtered into the renal tubules via the glomerular basement membrane. GFR is calculated as the total of all single-nephron GFRs in both kidneys.
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