One of the first drugs to be approved for use in treatment of acquired immune deficiency syndrome (AIDS) was azidothymidine (AZT). Complete the Lewis structure for AZT.
a. How many carbon atoms are hybridized?
b. How many carbon atoms are hybridized?
c. Which atom is hybridized?
d. How many bonds are in the molecule?
e. How many bonds are in the molecule?
f. What is the bond angle in the azide group?
g. What is the bond angle in the side group attached to the five-membered ring?
h. What is the hybridization of the oxygen atom in the group?

Respuesta :

Complete the Lewis structure for AZT.

What is AZT?

Azidothymidine excatly was the first antiretroviral agents that was the approved for use for the  treating HIV infection in the United States [1987] and was the  subsequently frequently used in antiretroviral regiments for so many years.

a- When the carbonate atomic are  bonded to 4 other atoms the hybridization is said to be sp3 type. Here 1 s orbitals and 3 p orbitals in the same type  shell of an atomic combine to form 4 new equivalents orbitals.To  the arrangements is tetrahedral within a bonds angles of  109.5o.

b-When the carbonate atomic are  bonded to 4 other atoms the hybridization is said to be sp3 type. Here 1 s orbitals and 3 p orbitals in the same type  shell of an atomic combine to form 4 new equivalents orbitals.To  the arrangements is tetrahedral within a bonds angles of  109.5o.

C-The 2s and all the three (3p) orbitals of carbon by the  hybridise to form 4 sp3 orbitals.

d,e-There are 4 types of bond's or interactions: there are ionic, covalent, and  hydrogen bonds, and van der Waals interactions.

f-The azide bond angle, ∠N(1)-N(2)-N(3), is 173.6°, 173.2° and 171.5° in AZT, CH3N3 and HN3, respectively, which clearly the indicated a non-linear  asymmetrical chains structures.

g-Hence there are 5 pi bond's presented in this is  molecules. f. Since it is N atomic undergoes to the sp hybridization, bond's ∆ is 180°.

h-The oxygenation is sp3 hybridised which means that it has 4 sp3 hybrids orbitals. 1 of the sp3 hybridized orbitals overlap with s orbitals from a hydrogen to form the O-H sigma bond's. One of the sp3 hybridized orbitals overlapping with an sp3 hybridised orbital from carbon to formulate the C-O sigma bonds.

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