A voltage difference across the plasma membrane when the neuron has been stimulated describes the resting membrane potential of a neuron.
A relatively static membrane potential that is commonly referred to as the trans-membrane voltage ground value. A cell's resting membrane potential is defined as the electrical potential difference across the plasma membrane when it is not excited. The electrical potential difference across a cell membrane has traditionally been expressed by its value inside the cell relative to the extracellular environment.
Once a cell has reached its resting potential, it can undergo depolarization. During depolarization, the membrane potential rapidly changes from negative to positive. For this rapid shift to occur within the cell, several actions must occur along the plasma membrane.
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