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When the kidney's own blood supply decreases, they release renin, which leads to secretions of aldosterone from the adrenal cortex.

Renin is an enzyme produced by certain kidney cells. It is a component of the renin-angiotensin-aldosterone system, which regulates blood pressure through a chain of reactions. Specifically, renin regulates the adrenal glands' synthesis of the hormone aldosterone.

  • Renin transforms angiotensinogen (a liver-produced precursor to angiotensin) into angiotensin I. Angiotensin is a hormone that causes constriction of the blood vessels.
  • Angiotensin I is then converted to angiotensin II. Angiotensin II constricts blood vessels and promotes aldosterone release.
  • Aldosterone helps the kidneys retain water and salt, thereby boosting the body's water content. This causes the blood pressure to rise.

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