In response to c. acid in duodenum, the hormone secretin is released by endocrine cells in the duodenal mucosa.
Secretin is a polypeptide that contains 27 amino acids. In response to H+ and fatty acids in the lumen, S cells in the duodenum produce secretin. Particularly, a pH of less than 4.5 indicates the entry of stomach contents, which starts the secretin release.
Secretin, a digestive hormone that controls gastric acid secretion and pH levels in the duodenum, is released by the wall of the upper portion of the small intestine (the duodenum).
A pancreatic fluid that is high in bicarbonate is secreted when secretin is present (45). By interacting with pancreatic ductal cells, secretin enters the bloodstream or intestinal lumen and increases the production of bicarbonate, which lowers the pH of the gastric chyme as it enters the small intestine.
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