In humans, one allele of the APOE gene, called APOE-c2, can result in a high tolerance of cholesterol Cholesterol is a vital substance for humans but may lead to heart disease in an older adult with a history of high cholesterol diets. High cholesterol diets are becoming more prevalent in the United States. Currently only about 2% of humans carry the APOE-12 allele Which of the following states a valid null hypothesis about the future distribution of APOE alleles in future generations in the United States? i. The APOE 2 ailele was the result of chance mutations so it is not possible to predict now its frequency will change in the future ii. As high cholesterol diets become more common in the United States, individuals with the APOE-42 allele will have a better survival rate from heart disease than those without the allele, so the allele will increase in frequency iii. The low frequency of the APOE-42 allele indicates it is probably a recessive allele, so it will become less frequent as the dominant allele becomes more frequent iv. The variant protects an individual from a condition that is only common among humans beyond reproductive age, so the frequency of the allele will likely not change much in the future because it is not influenced by natural selection