The allosteric inhibitory effector BPG binds to both the A form and the F form. Both forms show a lower affinity for O2 in the presence of BPG. However, the inhibitory effect of BPG is larger for HbA. The different O2 affinity indicated by the curves has been attributed to different BPG affinity for the two Hb forms. Complete the statement.

BPG binds tighter to _____________ which ____________its affinity for O2.