Answer:
Phosphoanhydride bonds in ATP
Explanation:
The history of ATP dates back to the 20's when Fiske and Subbarow sought a method for quantifying inorganic phosphate (Pi) in animal tissues. During the course of their experiment, they purified ATP and creatine phosphate from animal tissues. At that time the physiological importance of these phosphate compounds was not known. It took several years to discover that these compounds were energy carriers and that their breakage provides the energy necessary for muscle contraction. It was until 1941 that the concepts of phosphate compounds "rich" and "poor" in energy was formally presented by Lipmann in a review in which he analyzed his data and those obtained in other laboratories. Based on the knowledge available at that time, Lipmann proposed the following:
The energy derived from hydrolysis of a phosphate compound depends exclusively on the chemical nature of the bond that binds the phosphate residue to the rest of the molecule. The N-P bond of creatine phosphate, phosphoenolpyruvate enol phosphate, ATP and PPi phosphoanhydride linkages, and aspartyl phosphate acyl phosphate bond were typical energy-rich phosphate bonds.
