Which of the following is not a requirement for effective oral drug delivery of protein and peptide drug?
1) Protection of the drug from degradation while in the harsh environment of the digestive tract
2) Consistent absorption of the drug in a manner that meets Bioavailability requirements
3) Consistent release of the drug so that it enters the bloodstream in a reproducible manner
4) Delivery of the drug through the GI tract or other organ and maintenance of pharmacologic effect similar to IV injection
5) None of these