One of the characteristics of hormones and hormone signaling involves the concept of "high affinity receptors". We see many unique receptors throughout the body for various hormones. However, we can generally identify receptors as being present as either integral proteins embedded in the cell membrane of the cells in the target tissue, or the receptors being found in the cytoplasm of the cells in the target tissue. Compare and contract how the cells of the target tissue produce their physiologic response to the hormone when receptors are found in these two locations. Explain the general mechanism by which the response takes place in each case, and provide an example of a hormone (or class of hormone) for each mechanism.