Bind Serotonin receptors in cranial blood vessels, causing vasoconstriction. Abortive Inhibit neuropeptide release Can reduce symptoms in 30-90 minutes Can reduce productivity loss and disability Can predispose to serotonin syndrome Can be given multiple ways: PO, SL, IM, etc. What drug? a) Acetaminophen b) Sumatriptan c) Ibuprofen d) Naproxen