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Which of the following sequences is correct?

A) binding of a signaling molecule to its receptor → G protein activation → adenylyl cyclase activation → cAMP production → protein phosphorylation
B) binding of a signaling molecule to its receptor → G protein activation → phospholipase C activation → IP3 production → increase in cytoplasmic calcium concentration
C) diffusion of a signaling molecule across the plasma membrane → binding of the signaling molecule to its receptor → movement of the signaling molecule-receptor complex into the nucleus → transcription
D) binding of a growth factor to its receptor → phosphorylation cascade → activation of transcription factor → transcription
E) All of the choices are correct"